FINDINGS FROM THE FULL ANALYSIS (MEASURABLE AND NON-MEASURABLE LESIONS)

In the CNS-BICR full analysis set, the ORR was 73% (95% CI, 64-81) in the osimertinib plus chemotherapy group and 69% (95% CI, 59-78) in the osimertinib monotherapy group. Of note, 59% (n = 70) of patients assigned osimertinib plus chemotherapy achieved a CR to therapy compared with 43% (n = 45) of those assigned monotherapy. The median CNS DOR

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